Fig. 1 · Structure
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Rugonersen
Antisense Oligonucleotide
Rugonersen is a locked-nucleic acid (LNA)-modified antisense oligonucleotide targeting the ubiquitin-protein ligase E3A (UBE3A). This compound effectively reduces the silencing of UBE3A, which is implicated in Angelman syndrome, a severe neurodevelopmental disorder. Rugonersen is utilized in research aiming to restore UBE3A expression, providing insights into potential therapeutic strategies for this condition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2591587-57-2 |
| Applications | Antisense Oligonucleotide |
| Molecular Weight | 6530.30 |
| Synonyms | RG6091; RO7248824 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.