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RUNX-IN-2

RUNX Inhibitor

RUNX-IN-2 is a selective RUNX inhibitor that covalently binds to RUNX-binding sequences, effectively preventing RUNX proteins from interacting with their target sites. This compound induces p53-dependent apoptosis and demonstrates potent inhibitory effects on cancer cell proliferation. In preclinical models, RUNX-IN-2 shows significant inhibition of tumor growth in PANC-1 xenograft mice, highlighting its potential for cancer therapy. Its high alkylation efficiency and specificity make it a valuable tool for investigating RUNX-related pathways in various research applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2893777-88-1
Applications	RUNX Inhibitor
Formula	C₇₁H₈₈Cl₂N₂₄O₁₁
Molecular Weight	1524.52
SMILES	O=C(C1=NC(NC(CCNC(CCCC2=CC=C(N(CCCl)CCCl)C=C2)=O)=O)=CN1C)NC3=CN(C)C(C(NC4=CN(C)C(C(NC5=CN(C)C(C(NCCCC(NC6=CN(C)C(C(NC7=CN(C)C(C(NC8=CN(C)C(C(NC9=CN(C)C(C(NCCCN(C)C)=O)=C9)=O)=C8)=O)=C7)=O)=C6)=O)=O)=N5)=O)=C4)=O)=N3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.