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Ruscogenin

Name: Ruscogenin
Brand: Adooq Bioscience
SKU: A14699
Availability: InStock

Cat. No. A14699 CAS 472-11-7

Ruscogenin (RUS), first isolated from Ruscus aculeatus, is also a major steroidal sapogenin of the traditional Chinese herb Radix Ophiopogon japonicus.

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Biological Activity

Target & Activity

Target	Activity	Value
NLRP3

Cellular Effect

Cell Line	Activity	Value	Description	Reference
BXPC-3	IC50	7.32 μM	Anticancer activity against human BXPC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36332549]
SW1990	IC50	8.14 μM	Anticancer activity against human SW1990 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36332549]
THP-1	IC50	2.27 μM	Anticoagulant activity in human THP1 cells assessed as inhibition of TNF-alpha-stimulated tissue factor expression incubated 1 hr before TNFalpha challenge measured after 5 hrs	[PMID: 20561785]

Specifications

Manufacturer	Adooq Bioscience
CAS Number	472-11-7
Formula	C₂₇H₄₂O₄
Molecular Weight	430.62
SMILES	CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(C(CC(C6)O)O)C)C)C)OC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

Solvent	Reported Solubility
DMSO	75 mg/mL (174.17 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.