Ruzaltatug

Ruzaltatug is a humanized IgG1 monoclonal antibody engineered to specifically target ERBB3, also known as HER3. This receptor is a critical component of the EGFR family, known for its role in promoting tumor growth and conferring resistance to targeted cancer therapies. By binding to ERBB3, Ruzaltatug effectively inhibits key downstream signaling pathways, including PI3K/AKT, thereby potentially reducing cancer cell proliferation and enhancing cell death. Additionally, as a humanized IgG1 antibody, Ruzaltatug is capable of mediating antibody-dependent cellular cytotoxicity (ADCC), adding a mechanism that may contribute to its therapeutic efficacy. Recommended isotype controls for this antibody are Human IgG1 kappa, Isotype Control, to ensure accurate experimental results.

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Product Details

Manufacturer Adooq Bioscience
CAS Number 2981438-63-3

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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