Apabetalone (RVX-208)

Catalog No.: A13956

BET bromodomain inhibitor

Apabetalone (RVX-208)

Apabetalone (RVX-208) Chemical Structure

CAS NO. 1044870-39-4

RVX-208 is a potent BET bromodomain inhibitor with IC50 of 0.510 uM for BD2, about 170-fold selectivity over BD1.

Availability: In stock

Package Price Qty
10 mg
$100.00
25 mg
$200.00
50 mg
$350.00
10mM * 1mL in DMSO
$75.00
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Biological Activity

RVX-208 is a potent BET bromodomain inhibitor with IC50 of 0.510 uM for BD2, about 170-fold selectivity over BD1.
Targets
BD2 (Cell-free assay)
0.51 μM
In vitro (25°C) DMSO 63 mg/mL (170.08 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% CMC Na (1N HCl, PH 2.5-3.0) 7 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27 mL 134.99 mL 269.98 mL
0.5 mM 5.4 mL 27 mL 54 mL
1 mM 2.7 mL 13.5 mL 27 mL
5 mM 0.54 mL 2.7 mL 5.4 mL

*The above data is based on the productmolecular weight 370.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13956
Actions Inhibitor
CAS No. 1044870-39-4
Formula C20H22N2O5
M. Wt 370.4
Purity >98%
Synonyms RVX-000222
SMILES CC1=CC(=CC(=C1OCCO)C)C2=NC(=O)C3=C(C=C(C=C3N2)OC)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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