Fig. 1 · Structure
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RWJ52353
α2D Receptor Ligand
RWJ52353 is a selective ligand targeting the α2D adrenoceptor, with notable binding affinities for the α2A, α2B, and α1 receptors, exhibiting Ki values of 1.5, 254, 621, and 443 nM, respectively. This compound demonstrates significant analgesic activity, as evidenced by its efficacy in the mouse abdominal irritation test, where it has an ED50 of 15.1 mg/kg. RWJ52353 is valuable for studies investigating pain mechanisms and the role of α2 adrenoceptors in analgesia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 245744-10-9 |
| Applications | α2D Receptor Ligand |
| Formula | C11H10N2S |
| Molecular Weight | 202.28 |
| SMILES | C1(C2=CCCC3=C2C=CS3)=CN=CN1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.