Fig. 1 · Structure
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RXPA 380
ACE Inhibitor
RXPA 380 is a potent C-terminal specific inhibitor of angiotensin-converting enzyme (ACE), displaying a Ki of 3 nM. It effectively inhibits C-domain mutants of human recombinant ACE, with an IC50 value of 2.5 nM. This compound serves as a valuable tool for studying ACE-related pathways and has potential applications in cardiovascular research and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 564479-79-4 |
| Applications | ACE Inhibitor |
| Formula | C33H36N3O7P |
| Molecular Weight | 617.63 |
| SMILES | O=C(O)[C@H](CC1=CNC2=CC=CC=C12)NC(C3C(P([C@@H](NC(OCC4=CC=CC=C4)=O)CC5=CC=CC=C5)(O)=O)CCC3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.