Fig. 1 · Structure
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RYL-552S
PfNDH2 Inhibitor
RYL-552S is a selective inhibitor of PfNDH2, a crucial enzyme in the electron transport chain of Plasmodium falciparum. This compound demonstrates potent efficacy against drug-resistant strains of the parasite, effectively eliminating asexual blood-stage forms in vitro. Its mechanism of action makes RYL-552S a valuable tool for studying antimalarial resistance and developing new therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1801444-69-8 |
| Applications | PfNDH2 Inhibitor |
| Formula | C24H17F4NOS |
| Molecular Weight | 443.46 |
| SMILES | O=C1C2=C(NC(C3=CC=C(CC4=CC=C(C=C4)SC(F)(F)F)C=C3)=C1C)C=CC=C2F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.