Fig. 1 · Structure
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(S)-3-Hydroxy Midostaurin
Kinases Inhibitor
(S)-3-Hydroxy Midostaurin is a selective kinase inhibitor targeting various kinases, including VEGFR-2, TRK-A, and FLT3, with IC50 values less than 400 nM. As a minor metabolite of midostaurin, it is produced through the hepatic CYP3A4 enzyme. This compound shows promise for research applications in acute myeloid leukemia (AML) therapy, offering insights into kinase modulation in cancer treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 945260-14-0 |
| Applications | Kinases Inhibitor |
| Formula | C35H30N4O5 |
| Molecular Weight | 586.64 |
| Synonyms | (S)-CGP52421 |
| SMILES | O[C@@H]1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(C)[C@@H]([C@@H](C[C@](O6)([H])N7C5=C2C8=C7C=CC=C8)N(C(C9=CC=CC=C9)=O)C)OC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.