Fig. 1 · Structure
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S-8510 free base
Benzodiazepine Receptor Antagonist
S-8510 free base is an inverse agonist at the benzodiazepine receptor, demonstrating binding affinities with Kis of 34.6 nM and 36.2 nM for -GABA and +GABA, respectively. This compound exhibits significant biological activity that can modulate GABAergic neurotransmission, making it valuable for research into anxiety, sedation, and other neuropsychiatric disorders. Its utility in pharmacological studies offers insights into the mechanism of action of benzodiazepine derivatives and their implications in therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 151224-83-8 |
| Applications | Benzodiazepine Receptor Antagonist |
| Formula | C12H10N4O2 |
| Molecular Weight | 242.23 |
| Synonyms | SB-737552 free base |
| SMILES | C12=NC=C3C(NC(C4=NOC=C4)=N3)=C1COCC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.