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(S)-Desmethylcitalopram

Antidepressant

(S)-Desmethylcitalopram is the active metabolite of Citalopram and serves as a selective serotonin reuptake inhibitor (SSRI), primarily targeting serotonin transporter proteins. It exhibits significant antidepressant activity, which is relevant for the investigation and treatment of depressive disorders. Additionally, (S)-Desmethylcitalopram inhibits cytochrome P450 isoenzymes 2D6 and 2C19, demonstrating IC50 values of 39.5 μM and 53.5 μM, respectively. This compound is useful for research focused on pharmacokinetics and drug interactions within the context of psychiatric treatment.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	144025-14-9
Applications	Antidepressant
Formula	C₁₉H₁₉FN₂O
Molecular Weight	310.37
Synonyms	(S)-DCIT
SMILES	N#CC1=CC2=C([C@](CCCNC)(C3=CC=C(F)C=C3)OC2)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.