Fig. 1 · Structure
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(S)-Dexfadrostat
Aromatase Inhibitor
(S)-Dexfadrostat is a potent aromatase inhibitor with an IC50 of 4.6 nM in human placental microsomes. This compound is instrumental in studying estrogen-dependent conditions such as breast cancer and gynecomastia, as well as systemic lupus erythematosus. Its ability to effectively inhibit aromatase makes it a valuable tool for research in endocrine regulation and related pathologies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 102676-86-8 |
| Applications | Aromatase Inhibitor |
| Formula | C14H13N3 |
| Molecular Weight | 223.27 |
| Synonyms | (S)-Fadrozole; (S)-CGS 16949A free base; (S)-FAD286 |
| SMILES | N#CC1=CC=C([C@@H]2CCCC3=CN=CN23)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.