Fig. 1 · Structure
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(S)-Ebvaciclib
PF-06873600 S Enantiomer
(S)-Ebvaciclib is the S enantiomer of PF-06873600, a selective and orally bioavailable inhibitor of cyclin-dependent kinases (CDKs). This compound has shown potential in modulating cell cycle progression and is useful for research applications related to cancer therapeutics. Its specificity toward CDKs makes it a valuable tool for studying cell proliferation and relevant signaling pathways in various disease models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2185859-59-8 |
| Applications | PF-06873600 S Enantiomer |
| Formula | C20H27F2N5O4S |
| Molecular Weight | 471.52 |
| Synonyms | (S)-PF-06873600 |
| SMILES | O=C1C(C(F)F)=CC2=CN=C(NC3CCN(S(=O)(C)=O)CC3)N=C2N1[C@@H]4[C@@](C)(O)CCC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.