Fig. 1 · Structure
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(S)-(-)-Felodipine
Antihypertensive Agent
(S)-(-)-Felodipine is the S-enantiomer of Felodipine, functioning as a selective vasoselective calcium antagonist and serves as an antihypertensive agent. This compound effectively inhibits the activation of vascular effector cells and disrupts the contractile processes in vitro. In canine models, (S)-(-)-Felodipine has demonstrated the ability to reduce mean arterial blood pressure by approximately 20%. Additionally, it exhibits a high metabolic rate in liver microsomes from both rat and dog, making it a valuable reagent for cardiovascular research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 105618-03-9 |
| Applications | Antihypertensive Agent |
| Formula | C18H19Cl2NO4 |
| Molecular Weight | 384.25 |
| SMILES | CCOC(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=C(C(Cl)=CC=C2)Cl)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.