Fig. 1 · Structure
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S-Gem
Gemcitabine Prodrug
S-Gem is a TrxR-dependent prodrug of Gemcitabine, specifically designed for selective activation by thioredoxin reductase (TrxR). This compound exhibits reduced cytotoxicity when compared to Gemcitabine, making it a valuable tool for studying targeted cancer therapies. S-Gem is primarily utilized in research applications aimed at enhancing the therapeutic efficacy of chemotherapeutic agents while minimizing adverse effects in cancer treatment protocols.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2169925-98-6 |
| Applications | Gemcitabine Prodrug |
| Formula | C13H15F2N3O6S2 |
| Molecular Weight | 411.40 |
| SMILES | FC1([C@H](N2C(N=C(C=C2)NC(OC3CSSC3)=O)=O)O[C@@H]([C@H]1O)CO)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.