Fig. 1 · Structure
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(S)-GSK852
Diastereomer
(S)-GSK852 is a diastereomer of GSK852, functioning as a bromodomain and extraterminal (BET) protein inhibitor. It selectively targets the BD2 domain with a reported pIC50 of 7.9, demonstrating significant inhibitory potency. This reagent is valuable for research into epigenetic regulation and the role of BET proteins in various disease models, including cancer and inflammation. Its unique diastereomeric structure may provide insights into the modulation of BET-associated pathways and potential therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2305919-51-9 |
| Applications | Diastereomer |
| Formula | C24H26N2O4 |
| Molecular Weight | 406.47 |
| SMILES | O=C(C1=CC(C(NC)=O)=C2OC[C@](C3=CC=CC=C3)(C)C2=C1)N[C@H]4[C@]5([H])C[C@H](O)C[C@@]54[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.