Fig. 1 · Structure
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(S)-Human enteropeptidase-IN-1
Enteropeptidase Inhibitor
(S)-Human enteropeptidase-IN-1 is a potent inhibitor of enteropeptidase, exhibiting low systemic exposure with an initial IC50 of 26 nM and an apparent IC50 of 1.8 nM. This compound enhances fecal protein output and effectively reduces body weight in diet-induced obese rat models. (S)-Human enteropeptidase-IN-1 operates through a reversible covalent mechanism, extending the duration of enzyme inactivation. It is valuable for research focused on obesity and metabolic regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1802891-23-1 |
| Applications | Enteropeptidase Inhibitor |
| Formula | C20H18N4O7 |
| Molecular Weight | 426.38 |
| SMILES | O=C([C@@]1(CC(O)=O)CC(C2=CC=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=C2)=NO1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.