Fig. 1 · Structure
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(S)-Opnurasib
KRAS G12C Inhibitor
(S)-Opnurasib is a potent and selective covalent inhibitor targeting KRAS G12C. This compound exhibits significant antitumor activity, making it a valuable tool for cancer research focused on KRAS-driven malignancies. Its oral bioavailability and specificity for the mutant KRAS G12C offer promising avenues for therapeutic exploration and development in oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2653994-10-4 |
| Applications | KRAS G12C Inhibitor |
| Formula | C29H28ClN7OS |
| Molecular Weight | 558.10 |
| Synonyms | (S)-JDQ-443; (S)-NVP-JDQ443 |
| SMILES | O=C(C=C)N1CC2(C1)CC(N3N=C(C4=CC=C5C(C=NN5C)=C4)[C@@]([C@@]6=C(Cl)C(C)=CC7=C6C=NN7)=C3C)C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.