(S)-PI3Kα-IN-4 is a highly selective inhibitor of the phosphoinositide 3-kinase alpha (PI3Kα) isoform, demonstrating an IC50 value of 2.3 nM. This compound exhibits significant selectivity, with 38.3-fold preference for PI3Kα over PI3Kβ, and more than 4-fold selectivity compared to PI3Kδ and PI3Kγ. (S)-PI3Kα-IN-4 is suitable for research applications focusing on cancer biology, particularly in studies aimed at understanding the role of PI3Kα in tumorigenesis and therapeutic resistance.
(S)-PI3Kα-IN-4 is a highly selective inhibitor of the phosphoinositide 3-kinase alpha (PI3Kα) isoform, demonstrating an IC50 value of 2.3 nM. This compound exhibits significant selectivity, with 38.3-fold preference for PI3Kα over PI3Kβ, and more than 4-fold selectivity compared to PI3Kδ and PI3Kγ. (S)-PI3Kα-IN-4 is suitable for research applications focusing on cancer biology, particularly in studies aimed at understanding the role of PI3Kα in tumorigenesis and therapeutic resistance.
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