Fig. 1 · Structure
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(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA is an E3 ligase ligand-linker conjugate designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. This compound features the (S,R,S)-AHPC ligand along with a three-unit PEG linker, facilitating targeted protein degradation through the ubiquitin-proteasome system. It is suitable for studies involving E3 ligase modulation and the development of novel therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2417370-48-8 |
| Applications | E3 Ligase Ligand-Linker Conjugate |
| Formula | C38H56F3N5O13S3 |
| Molecular Weight | 944.07 |
| SMILES | O=C(N(C[C@@H]1OC(OC(C)C(C)S[S](C)(=O)=O)=O)[C@@H](C1)C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCN)=O.OC(C(F)(F)F)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.