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(S,S)-SARM1-IN-9

SARM1 Inhibitor

(S,S)-SARM1-IN-9 is a stereoselective inhibitor of SARM1, specifically targeting Cys311 within the autoregulatory ARM domain. By covalently modifying this cysteine residue, (S,S)-SARM1-IN-9 effectively blocks NADase activity in wild-type SARM1, while sparing SARM1C311A and SARM1C311S mutants. This compound has demonstrated efficacy in preventing vacor- and vincristine-induced axon degeneration in primary rodent dorsal root ganglion neurons, making it valuable for research into axon degeneration-related neurological disorders, such as chemotherapy-induced peripheral neuropathy.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3020765-70-9
Applications	SARM1 Inhibitor
Formula	C₂₅H₂₁N₃O₄
Molecular Weight	427.45
SMILES	C=CC(N1[C@@H](C2=CC=C(OCO3)C3=C2)C4=C(C[C@H]1C(NCC#C)=O)C5=CC=CC=C5N4)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.