Fig. 1 · Structure
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(S,S)-TAK-418
Histone Demethylase Inhibitor
(S,S)-TAK-418 is a potent inhibitor of lysine-specific demethylase 1 (LSD1), effectively normalizing aberrant gene expression associated with neurodevelopmental disorders. Research indicates that (S,S)-TAK-418 alleviates autism spectrum disorder (ASD)-like behaviors in rodent models exposed to maternal valproate or poly I:C. This compound exhibits diverse effects on gene expression across different biological models and developmental stages, highlighting its potential as a therapeutic agent in disorders such as autism spectrum disorder and schizophrenia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1818253-48-3 |
| Applications | Histone Demethylase Inhibitor |
| Formula | C17H25ClN2O2S |
| Molecular Weight | 356.91 |
| SMILES | O=C(NC1CCOCC1)C2=CSC([C@@H](C3)[C@H]3NCC4CC4)=C2.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.