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Fig. 1 · Structure
Cat. No.
A18990
CAS No.
6451-73-6
Formula
C19H21NO4
Mol. Weight
327.4

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S-Scoulerine

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A549 IC50 26.32 μM Cytotoxicity against human A549 cells assessed as cell viability measured after 72 hrs by MTT assay [PMID: 34406008]
GES1 IC50 95.3 μM Antiproliferative activity against human GES1 cells assessed as reduction in cell viability after 24 hrs by MTT assay [PMID: 35286954]
HeLa IC50 6.737 μM Cytotoxicity against human HeLa cells assessed as cell viability measured after 72 hrs by MTT assay [PMID: 34406008]
HGC-27 IC50 6.1 μM Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability after 24 hrs by MTT assay [PMID: 35286954]
HRPE EC50 3.545 μM Induction of mitotic arrest in HRPE Cells overexpressing MYC measured for 24 hrs by acridine orange staining based fluorescence microscopic analysis [PMID: 34406008]
HRPE EC50 3.595 μM Induction of mitotic arrest in HRPE Cells overexpressing MYC assessed as polyploidy measured for 48 hrs by acridine orange staining based fluorescence microscopic analysis [PMID: 34406008]
HRPE IC50 4.065 μM Cytotoxicity against HRPE cells overexpressing MYC assessed as cell viability measured after 72 hrs by MTT assay [PMID: 34406008]
HRPE IC50 4.622 μM Cytotoxicity against HRPE cells overexpressing MYC/Bcl2 assessed as cell viability measured after 72 hrs by MTT assay [PMID: 34406008]
MDA-MB-231 IC50 7.324 μM Cytotoxicity against human MDA-MB-231 cells assessed as cell viability measured after 72 hrs by MTT assay [PMID: 34406008]
MGC-803 IC50 12.6 μM Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 24 hrs by MTT assay [PMID: 35286954]
NCI-H23 IC50 2.541 μM Cytotoxicity against human NCI-H23 cells harboring MYC assessed as cell viability measured after 72 hrs by MTT assay [PMID: 34406008]
SW480 IC50 4.237 μM Cytotoxicity against human SW480 cells assessed as cell viability measured after 72 hrs by MTT assay [PMID: 34406008]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 6451-73-6
Formula C19H21NO4
Molecular Weight 327.4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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