Fig. 1 · Structure
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(S)-Tersolisib
S-enantiomer
(S)-Tersolisib is the S-enantiomer of STX-478, a selective inhibitor of PI3Kα mutants. This compound effectively prevents metabolic dysfunction and exhibits notable antitumor activity in xenograft mouse models harboring PI3Kα mutant tumors. It serves as a valuable research tool for studying the therapeutic potential of targeting PI3Kα mutations in cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2883540-91-6 |
| Applications | S-enantiomer |
| Formula | C16H12F5N5O2 |
| Molecular Weight | 401.29 |
| Synonyms | (S)-STX-478; (S)-STX-478-101; (S)-LY4064809 |
| SMILES | NC1=NC=C(C=N1)NC(N[C@@H](C2=C(C3=CC(F)=CC(F)=C3O2)C)C(F)(F)F)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.