Fig. 1 · Structure
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S-Trityl-L-cysteine
Eg5 Inhibitor
S-Trityl-L-cysteine is a selective allosteric inhibitor of kinesin Eg5, demonstrating an IC50 of 1 μM for the inhibition of basal ATPase activity, and 140 nM for microtubule-activated ATPase activity. This compound exhibits significant antitumor properties, making it a valuable tool for cancer research and studies focused on cell division mechanics. Its targeted inhibition of Eg5 highlights its potential applications in exploring therapeutic interventions in malignancies driven by abnormal mitotic processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2799-07-7 |
| Applications | Eg5 Inhibitor |
| Formula | C22H21NO2S |
| Molecular Weight | 363.47 |
| Synonyms | NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine |
| SMILES | N[C@@H](CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.