Fig. 1 · Structure
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(S)-VU0637120
Y4R Antagonist
(S)-VU0637120 is a selective antagonist of the Y4 receptor (Y4R), demonstrating effective inhibition of pancreatic polypeptide (PP) binding with an IC50 value of 2.7 μM. This compound interacts with the allosteric site within the core region of the Y4R transmembrane structure, exhibiting a KB value of 300-400 nM. (S)-VU0637120 has potential applications in metabolic disease research, allowing for the exploration of Y4R modulation in related biological pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1175940-86-9 |
| Applications | Y4R Antagonist |
| Formula | C16H19N3O5S2 |
| Molecular Weight | 397.47 |
| SMILES | O=C([C@H]1N(CCCC1)S(C)(=O)=O)NC2=NC3=CC(OCCO4)=C4C=C3S2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.