Fig. 1 · Structure
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(S)-Zovegalisib
S-enantiomer of of RLY-2608
(S)-Zovegalisib, the S-enantiomer of RLY-2608, is a novel allosteric inhibitor of PI3Kα, selectively targeting mutant forms of the enzyme. It demonstrates potent anti-tumor activity, making it a valuable compound for cancer research. This reagent is particularly useful in studies focused on the role of PI3Kα mutations in tumorigenesis and therapeutic responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2733573-93-6 |
| Applications | S-enantiomer of of RLY-2608 |
| Formula | C29H14ClF5N6O2 |
| Molecular Weight | 608.91 |
| Synonyms | (S)-RLY-2608 |
| SMILES | O=C1N[C@H](C2=CC(F)=CC=C2Cl)C(C1=C3)=C(NC(C4=CC(F)=CC(C(F)(F)F)=C4)=O)C=C3C5=C(C#N)N6C(C=C5)=NC=N6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.