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- Ethan L. Morgan, .et al. STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle, PLoS Pathog, 2018, Apr; 14(4): e1006975 PMID: 29630659
- Nishimura K, .et al. Effect of erythropoietin production induced by hypoxia on autophagy in HepG2 cells, Biochem Biophys Res Commun, 2018, Jan 1;495(1):1317-1321 PMID: 29191652
- Soleimani AH, .et al. Micellar nano-carriers for the delivery of STAT3 dimerization inhibitors to melanoma, Drug Deliv Transl Res, 2017, Aug;7(4):571-581 PMID: 28290050
|Storage||at -20°C 3 years Powder|
|Synonyms||S3I201, NSC74859 , NSC-74859|
|S3I-201 (NSC 74859) is a novel inhibitor of Stat3 that inhibits Stat3, Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ± 33 µM) and Stat3-dependent transcriptional activities.|
|Solubility (25°C) *||In vitro||DMSO||73 mg/mL (199.8 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||5% DMSO, 95% PEG 300||15 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||27.37 mL||136.84 mL||273.67mL|
|0.5 mM||5.47 mL||27.37 mL||54.73 mL|
|1 mM||2.74 mL||13.68 mL||27.37 mL|
|5 mM||0.55 mL||2.74 mL||5.47 mL|
*The above data is based on the productmolecular weight 365.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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