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- Bae WJ, .et al. PTPRD-inactivation-induced CXCL8 promotes angiogenesis and metastasis in gastric cancer and is inhibited. J Exp Clin Cancer Res, 2019, 38:484 PMID: 31805999
- Nishimura K, .et al. Effect of erythropoietin production induced by hypoxia on autophagy in HepG2 cells, Biochem Biophys Res Commun, 2018, Jan 1;495(1):1317-1321 PMID: 29191652
- Ethan L. Morgan, .et al. STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle, PLoS Pathog, 2018, Apr; 14(4): e1006975 PMID: 29630659
- Soleimani AH, .et al. Micellar nano-carriers for the delivery of STAT3 dimerization inhibitors to melanoma, Drug Deliv Transl Res, 2017, Aug;7(4):571-581 PMID: 28290050
Biological Activity
S3I-201 (NSC 74859) is a novel inhibitor of Stat3 that inhibits Stat3, Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ± 33 µM) and Stat3-dependent transcriptional activities.
Targets
| STAT3 (Cell-free assay) | ||||
| 86 μM |
| In vitro (25°C) | DMSO | 66 mg/mL (180.64 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+corn oil | 2 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.37 mL | 136.84 mL | 273.67 mL |
| 0.5 mM | 5.47 mL | 27.37 mL | 54.73 mL |
| 1 mM | 2.74 mL | 13.68 mL | 27.37 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.47 mL |
*The above data is based on the productmolecular weight 365.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10817 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 501919-59-1 |
| Formula | C16H15NO7S |
| M. Wt | 365.4 |
| Purity | >98% |
| Synonyms | S3I201, NSC74859 , NSC-74859 |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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