S3I-201 (NSC 74859)

Catalog No.: A10817

Stat3 Inhibitor

S3I-201 (NSC 74859)

S3I-201 (NSC 74859) Chemical Structure

CAS NO. 501919-59-1

S3I-201 (NSC 74859) is a novel inhibitor of Stat3 that inhibits Stat3, Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ± 33 µM) and Stat3-dependent transcriptional activities.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $40.00

Special Price $36.00

10 mg

Regular Price: $70.00

Special Price $63.00

50 mg

Regular Price: $175.00

Special Price $157.50

100 mg

Regular Price: $330.00

Special Price $297.00

10mM * 1mL in DMSO

Regular Price: $60.00

Special Price $54.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

S3I-201 (NSC 74859) is a novel inhibitor of Stat3 that inhibits Stat3, Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ± 33 µM) and Stat3-dependent transcriptional activities.
Targets
STAT3 (Cell-free assay)
86 μM
In vitro (25°C) DMSO 73 mg/mL (199.8 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 5% DMSO, 95% PEG 300 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.37 mL 136.84 mL 273.67 mL
0.5 mM 5.47 mL 27.37 mL 54.73 mL
1 mM 2.74 mL 13.68 mL 27.37 mL
5 mM 0.55 mL 2.74 mL 5.47 mL

*The above data is based on the productmolecular weight 365.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10817
Actions Inhibitor
M. Wt 365.4
Formula C16H15NO7S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 501919-59-1
Synonyms S3I201, NSC74859 , NSC-74859
SMILES CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O

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