Fig. 1 · Structure
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S7958
TAS2R8 Antagonist
S7958 is a selective antagonist of the TAS2R8 bitter taste receptor, exhibiting an IC50 value of 0.06 μM. This compound primarily inhibits the perception of bitterness from substances such as coffee and active pharmaceutical ingredients by targeting TAS2R8 specifically, with minimal inhibition of TASR8 and TAS2R39. S7958 is valuable for research applications focused on understanding and mitigating bitterness in oral formulations, thereby aiding the development of more palatable pharmaceutical products.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1217341-48-4 |
| Applications | TAS2R8 Antagonist |
| Formula | C21H23N5O4 |
| Molecular Weight | 409.44 |
| SMILES | O=C1N(C(C(C)(C)N1CC2=CC(O)=CC=C2)=O)C3=CN(CC4=C(C)ON=C4C)N=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.