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Saccharolactone

β-glucuronidase Inhibitor

Saccharolactone is a potent inhibitor of β-glucuronidase, targeting this enzyme to significantly reduce biliary endogenous β-glucuronidase activity in rat bile. It stabilizes glucuronide metabolites in vitro, contributing to its effectiveness in research settings. Additionally, Saccharolactone strongly inhibits the cytochrome P450 isoforms CYP1A2, CYP2D6, CYP3A4, and CYP2C8, with an IC50 of less than 4 mM, making it valuable for studying drug metabolism and pharmacokinetics.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	389-36-6
Applications	β-glucuronidase Inhibitor
Formula	C₆H₈O₇
Molecular Weight	192.12
SMILES	OC([C@H]([C@]1([H])[C@@H]([C@H](C(O1)=O)O)O)O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.