Fig. 1 · Structure
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Safotibant
BKB1R Antagonist
Safotibant is a selective antagonist of the kinin B1 receptor (BKB1R), exhibiting Ki values of 0.35 nM and 6.5 nM for human and mouse BKB1R, respectively. This compound demonstrates significant analgesic and anti-inflammatory effects in mouse models, making it a valuable tool for research in pain management and inflammatory response studies. Its precise targeting of BKB1R underscores its potential applications in therapeutic development and investigation of kinin-mediated signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 633698-99-4 |
| Applications | BKB1R Antagonist |
| Formula | C25H34N4O5S |
| Molecular Weight | 502.63 |
| Synonyms | LF22-0542 |
| SMILES | O=C(COCCN(S(=O)(C1=C(C)C=C(OC)C=C1C)=O)C)N(CC2=CC=C(C3=NCCN3)C=C2)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.