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Fig. 1 · Structure
Cat. No.
A10822
CAS No.
53003-10-4
Formula
C42H70O11
Mol. Weight
751

Documents & Downloads

Salinomycin (Procoxacin)

Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent.

In Stock

Publications for Salinomycin

2 publications citing this product

  1. Hitesh Kumar, .et al. , Int J Pharm, 2023, Aug 25;643:123226 PMID: 37451328
  2. Win Sen Heng, .et al. , Molecules, 2021, Jan; 26(2): 399 PMID: 33451160
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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
2008 IC50 3.2 μM Cytotoxicity against human OV2008 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay [PMID: 28651817]
2008 IC50 4.78 μM Cytotoxicity against human OV2008 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay [PMID: 28651817]
2008 IC50 7.44 μM Cytotoxicity against human OV2008 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay [PMID: 28651817]
4T1 IC50 3.78 μM Cytotoxicity against mouse 4T1 cells assessed as cell growth inhibition after 48 hrs by MTS assay [PMID: 29466777]
4T1 IC50 3.78 μM Antiproliferative activity against mouse 4T1 cells by MTT assay [PMID: 30684870]
A549 IC50 3.98 μM Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTS assay [PMID: 29466777]
A549 IC50 3.98 μM Antiproliferative activity against human A549 cells by MTT assay [PMID: 30684870]
BALB/3T3 IC50 27.76 μM Antiproliferative activity against mouse BALB/3T3 cells after 72 hrs [PMID: 26163197]
BALB/3T3 IC50 28.08 μM Cytotoxicity against mouse BALB/3T3 cells incubated for 72 hrs by MTT assay [PMID: 23079523]
BALB/3T3 IC50 9.33 μM Antiproliferative activity against mouse BALB/3T3 cells assessed as growth inhibition after 72 hrs by SRB method [PMID: 25644674]
BEAS-2B IC50 13.07 μM Cytotoxicity against human BEAS2B cells assessed as cell growth inhibition after 48 hrs by MTS assay [PMID: 29466777]
BT-474 CC50 14 μM Cytotoxicity against human BT474 cells after 48 hrs by MTS assay 10.1039/C6MD00328A
Caco-2 IC50 12.99 μM Antiproliferative activity against human Caco2 cells by MTT assay [PMID: 30684870]
DU-145 CC50 > 20 μM Cytotoxicity against human DU145 cells after 48 hrs by MTS assay 10.1039/C6MD00328A
HEK293 IC50 195 nM Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay [PMID: 29466777]
HEK293 IC50 329.5 nM Cytotoxicity against doxycycline inducible T-Rex/K-Ras G12V HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay [PMID: 29466777]
HeLa IC50 0.32 μM Antiproliferative activity against human HeLa cells by MTT assay [PMID: 30684870]
HeLa IC50 4.49 μM Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 48 hrs by MTS assay [PMID: 29466777]
HepG2 IC50 24.5 μM Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay [PMID: 30871771]
HGC-27 IC50 2.57 μM Cytotoxicity against human HGC27 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay [PMID: 28262526]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 53003-10-4
Formula C42H70O11
Molecular Weight 751
Synonyms Procoxacin
SMILES
CC[C@@H](C(=O)[C@@H](C)[C@@H](O)[C@H](C)[C@@H]1O[C@@H]([C@@H](CC)C(=O)O)CC[C@@H]1C)[C@H]1O[C@]2(C=C[C@@H](O)[C@]3(CC[C@@](C)([C@H]4CC[C@](O)(CC)[C@H](C)O4)O3)O2)[C@H](C)C[C@@H]1C

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 95 mg/mL (126.49 mM)
Water Insoluble
Ethanol 75 mg/mL (99.86 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Publications

2 publications citing this product

  1. Hitesh Kumar, .et al. , Int J Pharm, 2023, Aug 25;643:123226 PMID: 37451328
  2. Win Sen Heng, .et al. , Molecules, 2021, Jan; 26(2): 399 PMID: 33451160

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