Fig. 1 · Structure
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Samelisant
H3R Inverse Agonist
Samelisant (SUVN-G3031) is a potent and selective inverse agonist of the histamine H3 receptor (H3R), demonstrating significant brain penetration and oral bioavailability. It exhibits comparable binding affinities for human (Ki=8.7 nM) and rat H3Rs (Ki=9.8 nM), indicating a lack of inter-species variability. This compound is suitable for research into sleep-related disorders, providing insights into potential therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 1394808-20-8 |
| Applications | H3R Inverse Agonist |
| Formula | C21H33Cl2N3O3 |
| Molecular Weight | 446.41 |
| Synonyms | SUVN-G3031 |
| SMILES | O=C(CN1CCOCC1)NC2=CC=C(C=C2)OC3CCN(CC3)C4CCC4.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.