Fig. 1 · Structure
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Sampatrilat
Vasopeptidase Inhibitor
Sampatrilat is a potent vasopeptidase inhibitor targeting angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP). This compound exhibits superior potency towards the C-domain of ACE (Ki = 13.8 nM) compared to the N-domain (Ki = 171.9 nM). Sampatrilat is valuable for research applications involving chronic heart failure and the regulation of blood pressure.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 129981-36-8 |
| Applications | Vasopeptidase Inhibitor |
| Formula | C26H40N4O9S |
| Molecular Weight | 584.68 |
| Synonyms | UK-81252 |
| SMILES | OC([C@H](CNC([C@@H](NS(C)(=O)=O)CCCCN)=O)CC1(CCCC1)C(N[C@H](C(O)=O)CC2=CC=C(O)C=C2)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.