Fig. 1 · Structure
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Sapitinib fumarate
ErbB1/2/3 Inhibitor
Sapitinib fumarate is a reversible, ATP-competitive inhibitor of the ErbB family, specifically targeting EGFR, ErbB2, and ErbB3 with IC50 values of 4 nM, 3 nM, and 4 nM, respectively. This compound exhibits potent inhibition of cellular proliferation driven by aberrant ErbB signaling pathways. It is commonly employed in research focused on cancer biology, particularly in studies investigating therapeutic resistance and receptor tyrosine kinase signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1196531-39-1 |
| Applications | ErbB1/2/3 Inhibitor |
| Formula | C31H33ClFN5O11 |
| Molecular Weight | 706.07 |
| Synonyms | AZD-8931 fumarate |
| SMILES | OC(/C=C/C(O)=O)=O.COC(C(OC1CCN(CC1)CC(NC)=O)=C2)=CC3=C2C(NC4=C(C(Cl)=CC=C4)F)=NC=N3.OC(/C=C/C(O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.