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(Sar1,Gly8)-Angiotensin II

AT1 Antagonist

(Sar1,Gly8)-Angiotensin II is a selective antagonist of the angiotensin II receptor subtype AT1, demonstrating a Ki of 52 nM for the AT2 receptor in rat adrenal tissue. This compound effectively inhibits dipsogenic responses induced by intracerebroventricular administration of angiotensin II, making it a valuable tool for studying the physiological roles of the renin-angiotensin system. Its applications include research into cardiovascular function, fluid regulation, and the central nervous system’s response to angiotensin II.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	51887-62-8
Applications	AT1 Antagonist
Formula	C₄₂H₆₅N₁₃O₁₀
Molecular Weight	912.05

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.