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SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays.
| In vitro | DMSO | 11 mg/mL (19.97 mM) | |
| Water | <1 mg/mL | ||
| Ethanol | <1 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.16 mL | 90.81 mL | 181.61 mL |
| 0.5 mM | 3.63 mL | 18.16 mL | 36.32 mL |
| 1 mM | 1.82 mL | 9.08 mL | 18.16 mL |
| 5 mM | 0.36 mL | 1.82 mL | 3.63 mL |
*The above data is based on the productmolecular weight 550.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21094 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1116743-46-4 |
| Formula | C25H23FN8O2S2 |
| M. Wt | 550.63 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | SAR 125844, SAR-125844 |
| SMILES | O=C(NCCN1CCOCC1)NC2=NC3=CC=C(SC4=NN=C5C=CC(C6=CC=C(F)C=C6)=NN54)C=C3S2 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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