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SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.16 mL | 90.81 mL | 181.61 mL |
| 0.5 mM | 3.63 mL | 18.16 mL | 36.32 mL |
| 1 mM | 1.82 mL | 9.08 mL | 18.16 mL |
| 5 mM | 0.36 mL | 1.82 mL | 3.63 mL |
*The above data is based on the productmolecular weight 550.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21094 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 550.63 |
| Formula | C25H23FN8O2S2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1116743-46-4 |
| Synonyms | SAR 125844, SAR-125844 |
| SMILES | O=C(NCCN1CCOCC1)NC2=NC3=CC=C(SC4=NN=C5C=CC(C6=CC=C(F)C=C6)=NN54)C=C3S2 |
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