Fig. 1 · Structure
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SAR629
Monoglyceride Lipase Inhibitor
SAR629 is a potent covalent inhibitor of monoglyceride lipase (MGL), which plays a pivotal role in the degradation of 2-arachidonoylglycerol (2-AG). By inhibiting MGL, SAR629 effectively increases 2-AG levels, thereby modulating endocannabinoid signaling pathways. This compound is valuable for studying the physiological roles of cannabinoids in various biological systems and has potential applications in neuroprotection and metabolic research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1221418-42-3 |
| Applications | Monoglyceride Lipase Inhibitor |
| Formula | C20H19F2N5O |
| Molecular Weight | 383.39 |
| SMILES | O=C(N1N=CN=C1)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.