Fig. 1 · Structure
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Saralasin
Angiotensin II Receptor Antagonist
Saralasin is an angiotensin II receptor antagonist that functions as a competitive inhibitor, exhibiting a Ki value of 0.32 nM for 74% of binding sites. This octapeptide analog of angiotensin II also displays partial agonist activity. Saralasin is valuable for research into renovascular hypertension and renin-dependent (angiotensinogenic) hypertension, providing insights into the modulatory effects of angiotensin II on blood pressure regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 34273-10-4 |
| Applications | Angiotensin II Receptor Antagonist |
| Formula | C42H65N13O10 |
| Molecular Weight | 912.05 |
| Synonyms | [Sar1,Ala8] Angiotensin II |
| SMILES | C([C@H](CC1=CN=CN1)NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC(CNC)=O)CCCNC(=N)N)=O)C(C)C)=O)=O)[C@@H](C)C)=O)(=O)N3[C@H](C(N[C@H](C(O)=O)C)=O)CCC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.