Fig. 1 · Structure
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SARM1-IN-2
SARM1 Inhibitor
SARM1-IN-2 is a potent SARM1 inhibitor with an IC50 of less than 1 μM, specifically designed to disrupt the binding of SARM1 to NAD+. This mechanism effectively inhibits axon regeneration, a critical process for neuronal recovery following axonal degeneration. SARM1-IN-2 is valuable for research into the pathways of axonal degeneration and potential therapeutic strategies aimed at enhancing neuronal repair.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2396592-52-0 |
| Applications | SARM1 Inhibitor |
| Formula | C16H14N4O2S |
| Molecular Weight | 326.37 |
| SMILES | N#CC1=C(NC2=C3C=CC(C)=NC3=CC=C2OC)SN(C)C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.