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SARS-CoV-2 Mpro-IN-50

pan-CoV Mpro Inhibitor

SARS-CoV-2 Mpro-IN-50 is a noncovalent inhibitor targeting the main protease (Mpro) of SARS-CoV-2, with an IC50 value of 14 nM. This compound also exhibits pan-coronavirus inhibitory activity, demonstrating IC50 values ranging from 20 to 190 nM against various coronaviruses, including SARS-CoV-1 and MERS. Additionally, SARS-CoV-2 Mpro-IN-50 shows significant antiviral efficacy against the SARS-CoV-2 omicron variant, with an EC50 of 22 nM. It is a valuable tool for research into coronavirus infections and potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3038701-72-0
Applications	pan-CoV Mpro Inhibitor
Formula	C₂₅H₂₅F₅N₆O₃
Molecular Weight	552.50
SMILES	FC1=CC([C@H]2[C@H](NC([C@H](NC(C(F)(F)F)=O)C(C)C)=O)CN(C(C3=NC=CN4C3=CN=C4)=O)CC2)=CC(F)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.