Satoprodil is a potent negative allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, specifically targeting the NR2B subunit with an IC50 value of 123 nM. This compound exhibits significant biological activity in regulating glutamatergic neurotransmission and has potential research applications in neuropharmacology, particularly in the study of pain, mood disorders, and neurodegenerative diseases.
Satoprodil is a potent negative allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor, specifically targeting the NR2B subunit with an IC50 value of 123 nM. This compound exhibits significant biological activity in regulating glutamatergic neurotransmission and has potential research applications in neuropharmacology, particularly in the study of pain, mood disorders, and neurodegenerative diseases.
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