SB-200646 is a selective antagonist of the 5-HT2B and 5-HT2C receptors, exhibiting pKi values of 7.5, 6.9, and 5.2 against these targets and the 5-HT2A receptor, respectively. This compound demonstrates oral bioactivity and displays notable electrophysiological and anxiolytic effects in vivo. It serves as a valuable tool for research into serotonergic modulation and its implications in anxiety-related disorders.
SB-200646 is a selective antagonist of the 5-HT2B and 5-HT2C receptors, exhibiting pKi values of 7.5, 6.9, and 5.2 against these targets and the 5-HT2A receptor, respectively. This compound demonstrates oral bioactivity and displays notable electrophysiological and anxiolytic effects in vivo. It serves as a valuable tool for research into serotonergic modulation and its implications in anxiety-related disorders.
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