Fig. 1 · Structure
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SB-200646A
5-HT2B/2C Receptor Antagonist
SB-200646A is a selective antagonist of the 5-HT2B and 5-HT2C receptors, exhibiting pKi values of 7.5 for 5-HT2B, 6.9 for 5-HT2C, and 5.2 for 5-HT2A, highlighting its specificity. This compound is orally active and demonstrates significant electrophysiological and anxiolytic effects in vivo, making it a valuable tool for research in neuropharmacology and the study of serotonin receptor-mediated pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 143797-62-0 |
| Applications | 5-HT2B/2C Receptor Antagonist |
| Formula | C15H15ClN4O |
| Molecular Weight | 302.76 |
| SMILES | O=C(NC1=CC=CN=C1)NC2=CC3=C(N(C)C=C3)C=C2.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.