SB-200646A is a selective antagonist of the 5-HT2B and 5-HT2C receptors, exhibiting pKi values of 7.5 for 5-HT2B, 6.9 for 5-HT2C, and 5.2 for 5-HT2A, highlighting its specificity. This compound is orally active and demonstrates significant electrophysiological and anxiolytic effects in vivo, making it a valuable tool for research in neuropharmacology and the study of serotonin receptor-mediated pathways.
SB-200646A is a selective antagonist of the 5-HT2B and 5-HT2C receptors, exhibiting pKi values of 7.5 for 5-HT2B, 6.9 for 5-HT2C, and 5.2 for 5-HT2A, highlighting its specificity. This compound is orally active and demonstrates significant electrophysiological and anxiolytic effects in vivo, making it a valuable tool for research in neuropharmacology and the study of serotonin receptor-mediated pathways.
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