Fig. 1 · Structure
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SB-215505
5-HT2B Receptor Antagonist
SB-215505 is a selective antagonist of the 5-HT2B receptor, exhibiting a pKi of 8.3 for this target and lower affinities for 5-HT2A (pKi 6.77) and 5-HT2C (pKi 7.66). This compound has been shown to enhance wakefulness and motor activity in rodent models. SB-215505 is useful for studying the role of 5-HT2B receptors in various physiological and behavioral processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 162100-15-4 |
| Applications | 5-HT2B Receptor Antagonist |
| Formula | C19H16ClN3O |
| Molecular Weight | 337.80 |
| SMILES | O=C(N1CCC2=C1C=C(Cl)C(C)=C2)NC3=C4C=CC=NC4=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.