SB-215505 is a selective antagonist of the 5-HT2B receptor, exhibiting a pKi of 8.3 for this target and lower affinities for 5-HT2A (pKi 6.77) and 5-HT2C (pKi 7.66). This compound has been shown to enhance wakefulness and motor activity in rodent models. SB-215505 is useful for studying the role of 5-HT2B receptors in various physiological and behavioral processes.
SB-215505 is a selective antagonist of the 5-HT2B receptor, exhibiting a pKi of 8.3 for this target and lower affinities for 5-HT2A (pKi 6.77) and 5-HT2C (pKi 7.66). This compound has been shown to enhance wakefulness and motor activity in rodent models. SB-215505 is useful for studying the role of 5-HT2B receptors in various physiological and behavioral processes.
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