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SB-247853

5-HT2c Receptor Antagonist

SB-247853 is a highly selective antagonist of the 5-HT2c receptor, which plays a crucial role in various physiological processes, including cardiovascular regulation. Research has demonstrated that SB-247853 can induce orthostatic intolerance during head-up tilting, highlighting its potential impact on cardiovascular responses. This compound is valuable for studying mechanisms underlying cardiovascular diseases and the role of serotonin receptor modulation in these conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	200711-10-0
Applications	5-HT2c Receptor Antagonist
Formula	C₂₂H₁₉F₃N₄O₂
Molecular Weight	428.41
SMILES	O=C(N1CCC2=C1C=C(C(F)(F)F)C(C)=C2)NC3=CC=C(OCC4=NC=CC=C4)N=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.