SB-247853

Catalog No.: A29888
5-HT2c Receptor Antagonist
SB-247853 is a highly selective antagonist of the 5-HT2c receptor, which plays a crucial role in various physiological processes, including cardiovascular regulation. Research has demonstrated that SB-247853 can induce orthostatic intolerance during head-up tilting, highlighting its potential impact on cardiovascular responses. This compound is valuable for studying mechanisms underlying cardiovascular diseases and the role of serotonin receptor modulation in these conditions.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSB-247853 is a highly selective antagonist of the 5-HT2c receptor, which plays a crucial role in various physiological processes, including cardiovascular regulation. Research has demonstrated that SB-247853 can induce orthostatic intolerance during head-up tilting, highlighting its potential impact on cardiovascular responses. This compound is valuable for studying mechanisms underlying cardiovascular diseases and the role of serotonin receptor modulation in these conditions.
Product Information
Catalog NumA29888
FormulaC22H19F3N4O2
Molecular Weight428.41
CAS Number200711-10-0
SMILESO=C(N1CCC2=C1C=C(C(F)(F)F)C(C)=C2)NC3=CC=C(OCC4=NC=CC=C4)N=C3
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