SB-633825 is a potent ATP-competitive inhibitor targeting TIE2, LOK (STK10), and BRK, with IC50 values of 3.5 nM, 66 nM, and 150 nM, respectively. This compound effectively inhibits cancer cell proliferation and angiogenesis, making it a valuable tool for research on tumor growth and vascular development. Its selective inhibition profile supports studies aimed at understanding the roles of these kinases in cancer biology and therapeutic strategies.
SB-633825 is a potent ATP-competitive inhibitor targeting TIE2, LOK (STK10), and BRK, with IC50 values of 3.5 nM, 66 nM, and 150 nM, respectively. This compound effectively inhibits cancer cell proliferation and angiogenesis, making it a valuable tool for research on tumor growth and vascular development. Its selective inhibition profile supports studies aimed at understanding the roles of these kinases in cancer biology and therapeutic strategies.
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