Fig. 1 · Structure
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SB 714786
5-HT Receptor Antagonist
SB 714786 is a potent and selective antagonist of the 5-hydroxytryptamine 1D (5-HT1D) receptor. Engineered from a series of dual 5-HT1 receptor selective reuptake inhibitors, it represents the first highly potent compound targeting specifically the 5-HT1D subtype. With pKi values of 6.5, 6.7, 9.1, and 6.5 for 5-HT1A, 5-HT1B, 5-HT1D, and SerT receptors, respectively, SB 714786 exhibits remarkable selectivity for the 5-HT1D receptor while showing minimal intrinsic activity against other receptor subtypes. This specificity makes it a valuable pharmacological tool for investigating the role of 5-HT1D receptors in various biological contexts and potential therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 584555-10-2 |
| Applications | 5-HT Receptor Antagonist |
| Formula | C26H28N4O |
| Molecular Weight | 412.53 |
| SMILES | CC1=NC2=CC=CC(OCCN3CCN(CC3)CC4=C5N=CC=CC5=CC=C4)=C2C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.