Fig. 1 · Structure
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SB228357
5-HT2C/2B Receptor Antagonist
SB228357 is a selective and potent antagonist of the 5-HT2C and 5-HT2B receptors, exhibiting pKi values of 6.9, 8.0, and 9.0 for the 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. This compound demonstrates significant antidepressant and anxiolytic effects, making it valuable for research focused on mood disorders and anxiety-related conditions. Its oral bioavailability further enhances its utility in pharmacological investigations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 181629-93-6 |
| Applications | 5-HT2C/2B Receptor Antagonist |
| Formula | C22H17F4N3O2 |
| Molecular Weight | 431.38 |
| SMILES | O=C(N1CCC2=C1C=C(C(F)(F)F)C(OC)=C2)NC3=CC(C4=CC=CN=C4)=CC(F)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.