Fig. 1 · Structure
Documents & Downloads
SC-919
IP6K Inhibitor
SC-919 is a potent inhibitor of inositol phosphate kinases (IP6K) with IC50 values of < 5.2 nM for IP6K1, < 3.8 nM for IP6K2, and 0.65 nM for IP6K3. This compound effectively reduces intracellular levels of inositol pentakisphosphate (IP7), leading to the suppression of XPR1-mediated phosphate efflux from cells. SC-919 subsequently increases intracellular phosphate and ATP concentrations while lowering plasma phosphate levels, making it a valuable tool in research focused on chronic kidney disease and hyperphosphatemia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2245949-62-4 |
| Applications | IP6K Inhibitor |
| Formula | C19H16Cl2N2O4 |
| Molecular Weight | 407.25 |
| Synonyms | LI-2124 |
| SMILES | O=C1[C@@]2(CC[C@@H](CC2)OC3=C(C=C(C=N3)Cl)Cl)C4=CC(C(O)=O)=CC=C4N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.